The Haystead Lab



Selected Publications

A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo.
Crowe LB, Hughes PF, Alcorta DA, Osada T, Smith AP, Totzke J, Loiselle DR, Lutz ID, Gargesha M, Roy D, Roques J, Darr D, Lyerly HK, Spector NL, Haystead TAJ. ACS Chem Biol. 2017 Apr 21;12(4):1047-1055. doi: 10.1021/acschembio.7b00006. PMID: 28103010
Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.
Alwarawrah Y, Hughes P, Loiselle D, Carlson DA, Darr DB, Jordan JL, Xiong J, Hunter LM, Dubois LG, Thompson JW, Kulkarni MM, Ratcliff AN, Kwiek JJ, Haystead TA. Cell Chem Biol. 2016 Jun 23;23(6):678-88. doi: 10.1016/j.chembiol.2016.04.011. PMID: 27265747
An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target.
Howe MK, Speer BL, Hughes PF, Loiselle DR, Vasudevan S, Haystead TA. Antiviral Res. 2016 Jun;130:81-92. doi: 10.1016/j.antiviral.2016.03.017. PMID:27058774
Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.
Carlson DA, Franke AS, Weitzel DH, Speer BL, Hughes PF, Hagerty L, Fortner CN, Veal JM, Barta TE, Zieba BJ, Somlyo AV, Sutherland C, Deng JT, Walsh MP, MacDonald JA, Haystead TA. ACS Chem Biol. 2013 Dec 20;8(12):2715-23. doi: 10.1021/cb400407c. PMID:24070067
A highly selective Hsp90 affinity chromatography resin with a cleavable linker.
Hughes PF, Barrott JJ, Carlson DA, Loiselle DR, Speer BL, Bodoor K, Rund LA, Haystead TA. Bioorg Med Chem. 2012 May 15;20(10):3298-305. doi: 10.1016/j.bmc.2012.03.043. PMID:22520629
Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.
Barrott JJ, Hughes PF, Osada T, Yang XY, Hartman ZC, Loiselle DR, Spector NL, Neckers L, Rajaram N, Hu F, Ramanujam N, Vaidyanathan G, Zalutsky MR, Lyerly HK, Haystead TA. Chem Biol. 2013 Sep 19;20(9):1187-97. doi: 10.1016/j.chembiol.2013.08.004. PMID: 24035283
Hsp90, an unlikely ally in the war on cancer.
Barrott JJ, Haystead TA. FEBS J. 2013 Mar;280(6):1381-96. doi: 10.1111/febs.12147. Review. PMID: 23356585
Hsp90: a key target in HIV infection
Aaron P Smith , Timothy AJ Haystead Future Virology, Vol. 12, No. 2, Pages 55-59.